Effects ofHigh Altitude Exposure on Human Bone

    ZHUSuying1，SHI Zhiyou1，CHENYanli2，WU Yunhong1，23 (1.MedicineCollegeofXizangUniversity，Lhasa 85oooo，Xizang，China；

    2.School of Medicine，XizangMinzu University，Xianyang712o82，Shaanxi， China；

    3.Department of Endocrinology，Hospital of Chengdu Office of People's Government ofXizangAutonomousRegion，Chengdu 61oO41，Sichuan，China)

    Abstract：heprevaleefteoposisininaisigichrosltsthalthdalitfifefdegeddlle andthesituatioiteplateaueaisoresevereThfctsofplateuenvioentonoemineraldsityndosteoprosisdtoefurter studiedandelucidatedTisstudysummarizedtheefectsofplateauenvironmentonbonemineraldensityndbonemetabolisminiferent populationsalydhflaeeopsisfroFndsadteetioflaeoposisdil models，aiming to provide help for the prevention of osteoporosis inplateau areas.

    Keywords：Plateau；Osteoporosis；Bone metabolism

    高原为海拔超过 2 5 0 0 m 的地区。目前全球有超过1.4亿人永久居住在高原，占全球人口的 骨质疏松症作为最常见的骨骼疾病，是以骨密度降低和骨组织微结构破坏为主要特征的骨代谢性疾病，严重时易导致骨折3。2018年中国居民骨质疏松症首次流行病学调查提示4，50岁以上人群骨质疏松症患病率 1 9 . 2 % ......