中图分类号：R749.1 文献标识码：A文章编号：1006-1959(2025)09-0001-07

    Abstract：OeiTeihodalbodissfoatilsdalctio. MethodsTeAeimersdseasegenechipdatasetasdowloadedfrotheGEOdatabaseoftheNatioalCenterforBiotechologInfotion theUnitedStateeubsoferiseaseesedtouhdieretialexpresoaalysisdweightednpon networkaalysiseitoondialrelatedgnsraidfroteitCarta3dtabasedinterseedittforemetiodubees. Theintersectiongnsweeechedandaalyed，andaproteininteractioetworkaonstructedusingteStringdtabase.Tesulsre importedintoCytoscapesoftwareandtetop6gnsrankedinDegrewerescrendusingtheCCalgorit.ResultsAtotalof38down regulatedgenesdaedseedetialexpressolotalofseeyde co-expressooalysdolddioaGtal showedthatitasainlyolediloicalroceuchsangsiniochodrialorpeplicatioofiocodalo synthesisfniochodrialompoentsnditocondialaterialtrasportKGGpathaichentalysissodatitsinly enrichdnaroo‘scidabdsttaboallod relatedtoAlzier‘sseaseereeedbCyaesoftare：C，UFABPOosioo Alzheimersdiseaseenetasdobidwirityoffoatialsetosiitohodralubnsetied which can provide atheoretical basis for the role of mitochondrial dysfunction in Alzheimer's disease.

    Keywords：Bioinformatics;Alzheimer'sdisease;Mitochondria;Hub genes ......