FKTN突变扩张型心肌病相关基因的生物信息学分析

http://www.100md.com 2025年6月24日医学信息 2025年第9期

     中图分类号：R542.2 文献标识码：A文章编号：1006-1959(2025)09-0008-06

    DOI：10.3969/j.issn.1006-1959.2025.09.002

    Abstract：ObjectiveToinvestigatethepathogenicmechanismofFKTNgene mutationindilatedcardiomyopathy.MethodsTeGSE13828gene expressionproflrelatedtFKasdwladedfroteGenExpressonObsdatabaseandedierentialexpresionofKgene mutationmyocadaltiendalardalisueasaldTapRpacgessedtisplatfretiallexpd intheFKTgeneutantmyocardialtissendfurtereichmentaalysisofthdiferentillyexpressedgneswasperfodtfindte enrchentpathwaysProteninteractionetwokaalysisassedtofindtheeypathayproteisinthKeneutantmyocadaltisuead tofiditspathogenicmechanismandtherapeutictargetsResultsoifoaticsaalysisofFKTgneshowedtatcomparedwithtehealty controlgroup636ieetialypresentiutatioofcglatedde dow-regulatedAogtegatdGOalisdtatitasainlyentratedinatospodetaceai colgenfiberproiferationKEGGpathwayanalysisfoundtatteyweremainlyeicedinteinteractionofyokineytokinepto interleuki-igaingathactoiltainaligtaaligtad matrixeceteacteactiokaldatdC; regulatedgeesaldatleraediaspadalactdpmc microtubuleandproteinglycosylatioKEGGpathwayaalysisfoundthattheyweremainlycocentratedinmyocardialontractioilated cardiomyopathyandcalciumsignalingpathway.ProteininteractionnetworkanalysisfoundthatthekeynodegeneswereAsbl5andEfcab2. ConclusionThepathogenesisofmicewithFKTNmutation-relatedDCMmayberelatedtointracardiaccalciumhomeostasis ......

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