关键词：孟德尔随机化；牙周炎；炎症性肠病；基因变异

    中图分类号： R781.4+2 ；R574 文献标识码：A DOI：10.3969/j.issn.1006-1959.2025.13.017 文章编号：1006-1959(2025)13-0094-04

    Abstract：ObjetiveTvestigateeualelatiosetwnflamatowelsase(DdprodotiDbysigdel randomization.eodseargalegeoewideociatioudy(WAataofteEuroeanederatioofPerootoload theInteatioalIatoowelDiosorreedTigleedpSod withperiodontitseredsstrutalvaableely6d686.Atoapleethsedtoalyte causalrelatiosetodoiisdKfsdefoaliotrodeprocesofdata The MR-egger method was used to estimate the causal effect of periodontitis on IBD.The Cochran's Q test and F statistics were used to evaluate the consistencyotasulealotid the risk of IBD (OR=1.18，95 % CI1.09-1.28，Plt;0.oo1).Theestimationresultsofcausal effectof differentSNPswerebasicallyconsistent(Q=0.41， P =0.52， F =0).ConclusionsTheMendelianrandomizationstudyconfimedthecausalasociationbetweeperiodonitisandinflammatoryowel disease，providinganewperspectiveforunderstanding thepathogenesisandpreventionstrategiesof thesetwodiseases. ......