基于网络药理和分子对接分析槲皮素治疗类风湿关节炎的作用机制

http://www.100md.com 2025年8月27日医学信息 2025年第15期

     中图分类号：R593.22 文献标识码：A文章编号：1006-1959(2025)15-0001-08

    DOI：10.3969/j.issn.1006-1959.2025.15.001

    Mechanism of Quercetin in the Treatment of Rheumatoid Arthritis Based on Network Pharmacology and Molecular Docking Technology

    YANG Jingnan，LIYuxia，LINXuhong

    (Centerfor Translational Medicine，DepartmentofLaboratoryMedicine，HuaiheHospitalofHenan University，

    Kaifeng475000，Henan，China)

    Abstract：ObjectieTalyeehofecetiiraetofmatdtisyetkaldlaog techologyesctitafdodteleseee TargetPredictdaasladsbsdes infomationmaptoolsuedtbainteoogetsfquecetidRAlatedtargetseproteroteniteractio(etok wasconstructedringdeeoteseedyyoafaretesetioespod databaseforGfuctioadKEGGatyichentaalsTegensoteotsigificantencmentpatayereoverlapedwihep 10targetsfdieosulesodied ThroughCytosaas9echC，GFReotk whichtheendocrinesistancepathayasteostsignifcantBycomparingteighttargetgnesoteendocinesistancepathaywihte firstentargetgsielapgseaelyC、ATFEGFR9.eolecig andquercetinshowedgoodbindingactivity.ConclusionQuercetinmayregulateSRCand MMP9 inestrogenpathwaybyregulating E₂ level， further actontyrosineinasetrasmembanereceptorsIGF1RandEGFR ......

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