吴素琴 黄海齐 高英慧

    【摘要】目的：探讨达格列净对早期糖尿病肾病患者的临床疗效。方法：回顾性分析来自2020年12月至2021年6月期间内就诊于本院门诊或病房的60例早期糖尿病肾病患者的临床资料，对比两组患者治疗前后尿微量白蛋白/肌酐，及血清MCP-1、TNF-α水平。结果：相比于治疗前，两组治疗3个月后尿微量白蛋白/肌酐，及血清MCP-1、TNF-α水平均降低，且观察组较对照组低，差异有统计学意义(P<0.05)。结论：达格列净治疗早期糖尿病肾病的效果确切，可降低炎症因子水平，控制疾病进展。

    【关键词】早期糖尿病肾病；达格列净；尿微量白蛋白/肌酐；炎症因子

    The effect of dapagliflozin on renal function and serum MCP-1 and TNF-α levels in early diabetic nephropathy

    WU Suqin， HUANG Haiqi， GAO Yinghui Department of Endocrinology， Heze Hospital of Traditional Chinese Medicine， Shandong，Heze， Shandong 274000， China

    【Abstract】Objective：To investigate the clinical effect of dapagliflozin on patients with early diabetic nephropathy.Methods：A retrospective analysis of the clinical data of 60 patients with early diabetic nephropathy who were admitted to the outpatient or ward of our hospital from December 2020 to June 2021.The microalbuminuria/creatinine ......