瞿莉

    【摘要】目的：通过用电化学发光法(ECLIA)和化学发光微粒子免疫法(CMIA)分别检测相同血清标本中的丙肝抗体，将结果进行对比分析，判断两种方法的通用性。方法：选取2021年4月到2021年11月南京市妇幼保健院门诊及住院患者114例血液标本，分别以Cobas e601 电化学发光分析仪和Architect i2000 全自动发光免疫分析仪对患者血清丙肝抗体进行检测，比较检测结果。结果：Cobas e601 电化学发光分析仪检测丙肝抗体阴性率61.4%，临界率1.8%，阳性率36.8%，Architect i2000 全自动发光免疫分析仪检测丙肝抗体阴性率21.9%，临界率7.9%，阳性率70.2%，两组检测结果差异有统计学意义。结论：电化学发光法(ECLIA)和化学发光微粒子免疫法(CMIA)在检测血清丙肝抗体中结果差异较大，不可通用。

    【关键词】电化学发光法；化学发光微粒子免疫法；丙肝；血清；抗体

    Comparative study of two detection methods for hepatitis C antibody

    QU Li

    Maternity Hospital affiliated to Nanjing Medical University (Nanjing Maternal and Child Health Care Hospital)， Nanjing， Jiangsu 210004， China

    【Abstract】Objective：Hepatitis C antibodies in the same serum samples were detected by electrochemiluminescence immunoassay (ECLIA) and chemiluminescent microparticle immunoassay (CMIA) respectively， and the results were compared and analyzed to judge the universality of the two methods.Methods：A total of 114 blood samples from outpatients and inpatients in Nanjing Maternal and Child Health Hospital from April 2021 to November 2021 were selected. Serum hepatitis C antibodies were detected by Cobas E601 electrochemiluminescence analyzer and Architect I2000 automatic luminescence immunoassay analyzer ......