陈晨 程峰

    【摘要】目的：综合分析复发性流产(recurrent spontaneous abortion，RSA)患者进行抗核抗体相关检测的临床价值，为其诊断和治疗提供病例支持。方法：选定2020年6月—2021年9月在南京市妇幼保健院就诊的245例RSA患者作为观察组，另选择同时期已正常生育的健康女性142例作为对照组。运用化学发光法与免疫印迹法分别进行抗核抗体(antinuclear antibody，ANA)和抗核抗体谱(antinuclear antibody spectrum，ANAs)的检测。结果：观察组血清样本中ANA阳性结果为32例，阳性率13.06%，ANAs阳性结果为22例，阳性率8.98%，对照组血清样本中ANA阳性结果为4例，阳性率2.82%，ANAs阳性结果为3例，阳性率2.11%。两组ANA和ANAs阳性率比较，差异均有统计学意义(P0.05)。结论：抗核抗体和复发性流产的发生发展有一定的相关性，可能是反复流产的原因之一，但其具体机制机理尚待进一步明确。

    【关键词】抗核抗体(ANA)；抗核抗体谱(ANAs)；复发性流产(RSA)

    The value of antinuclear antibody detection in patients with recurrent miscarriage

    CHEN Chen， CHENG Feng The Nanjing Medical University obstetrics and Gynecology Hospital， Nanjing Maternal and Child Health Care Hospital，

    Nanjing， Jiangsu 210004， China

    【Abstract】Objective：The aim of this study is to provide scientific data reference for the diagnosis and treatment of recurrent spontaneous abortion by comprehensively analyzing the detection value of antinuclear antibodies in the serum of patients with recurrent spontaneous abortion (RSA). Methods：245 patients diagnosed with RSA in Nanjing Maternity and Child Health Hospital from June 2020 to September 2021 were selected as the observation group ......