宋良乾

    【摘要】支气管肺发育不良(bronchopulmonary dysplasia，BPD)是一种多见于早产儿，尤其是体重指标较低的早产儿群体中的慢性呼吸系统性疾病，一旦患有该病症不仅会导致早产儿的存活率降低，即使救治成功也会导致早产儿的远期生活质量受到一定不良影响。由此可见，对该类早产儿实施及时有效的防治至关重要，是提高早产儿存活率及近期、远期生活质量的关键。随着对BPD研究的不断深入，近几年相关研究大环内酯类抗生素在防治早产儿BPD中起到了重要应用价值。在此背景下，本文针对常见大环内酯类抗生素在BPD防治中的使用情况、使用效果，以及大环内酯类抗生素应用副作用展开综述，以此为临床相关医疗工作的开展提供一定参考。

    【关键词】大环内酯类抗生素；早产儿；支气管肺发育不良；防治效果；研究进展

    Research progress of macrolide antibiotics in the prevention and treatment of bronchopulmonary dysplasia in premature infants

    SONG Liangqian

    Jinchang Rehabilitation Hospital of Gansu Province， Jinchang， Gansu 737100， China

    【Abstract】Bronchopulmonary dysplasia (BPD) is a chronic respiratory disease commonly seen in the premature infants， especially those with low body mass index. Once the symptoms of this disease occur， the survival rate of the premature infants will be reduced. Even if the treatment is successful， the long-term quality of life of premature infants will be adversely affected. Therefore， it is very important to implement timely and effective prevention and treatment for such premature infants ......