杨霞霞 李伟霞

    【摘要】目的：对从不同部位分离出的革兰阴性多重耐药菌对头孢哌酮/舒巴坦的抗菌活性进行分析，为更准确的临床用药提供依据。方法：回顾分析本院2018年1月—2022年12月临床标本培养分离出的革兰阴性多重耐药菌，总结出头孢哌酮/舒巴坦相关的耐药特点。结果：2018年1月—2022年12月共检出临床常见革兰阴性多重耐药菌8730株，对头孢哌酮/舒巴坦具体的耐药率如下：比例最低的是产超广谱β-内酰胺酶大肠埃希菌，只有5.5%(228/4132)；比例最高的是碳青霉烯类耐药大肠埃希菌，达到了100%(161/161)；产超广谱β-内酰胺酶肺炎克雷伯菌16.7%(309/1854)；碳青霉烯类耐药肺炎克雷伯菌96.6%(312/323)；碳青霉烯类耐药鲍曼不动杆菌72.6%(1408/1939)；多重耐药铜绿假单胞菌82.6 %(265/321)。结论：在临床中常见的革兰阴性多重耐药菌，对头孢哌酮/舒巴坦的耐药率有较大的差异。临床需加强耐药菌监管，慎重选择抗生素治疗。

    【关键词】头孢哌酮/舒巴坦；革兰阴性菌；多重耐药；抗菌活性

    Antimicrobial activity of cefoperazone against gram-negative multi-drug resistant bacteria

    YANG Xiaxia， LI Weixia

    Affiliated Hospital of Jining Medical College of Shandong Province， Jining， Shandong 272029， China

    【Abstract】Objective：To analyze the antimicrobial activity of gram-negative multi-drug resistant bacteria isolated from different sites against cefoperazone sulbactam， so as to provide a basis for more accurate clinical drug use. Methods： The gram-negative multi-drug resistant bacteria isolated from clinical specimens in our hospital from January 2018 to December 2022 were analyzed retrospectively ......