研究齐多拉米双夫定片联合替诺福韦与依非韦伦治疗艾滋病的临床效果
1资料与方法,2结果,3讨论
【摘要】目的:探讨齐多拉米双夫定片联合替诺福韦与依非韦伦治疗艾滋病的效果。方法:选择2019年1月—2021年12月我院收治的艾滋病患者150例,按照数表随机的方式分组,对照组(n=75)采用齐多拉米双夫定片与奈韦拉平治疗,研究组(n=75)采用齐多拉米双夫定片联合替诺福韦与依非韦伦治疗。对比两组治疗前后HIV病毒载量、T淋巴细胞水平、血清炎性因子以及不良反应。结果:治疗6及12个月后,两组HIV病毒载量均较治疗前降低,且研究组低于对照组(P<0.05);治疗6及12个月后,两组CD4+细胞数量及CD4+/CD8+水平均较治疗前上升,且研究组高于对照组(P<0.05);治疗6及12个月后,两组CRP及TNF-α水平均较治疗前下降,且研究组低于对照组(P<0.05);对照组与研究组不良反应发生率比较差异不大,无统计学意义(P>0.05)。结论:齐多拉米双夫定片联合替诺福韦与依非韦伦治疗艾滋病的效果确切,可显著降低患者HIV病毒载量,减轻机体炎症反应,调剂免疫功能,值得推广。【关键词】齐多拉米双夫定片;替诺福韦;依非韦伦;艾滋病;免疫功能
To study the clinical effect of zidovudine and lamivudine tablets combinded with tenofovir and efavirenz in the treatment of AIDS
SUN Xinghong
1.The Third People’s Hospital of Jiangdu District, Yangzhou City, Jiangdu, Jiangsu 225200, China; 2.Jiangdu District Bridge Central Health Center of Yangzhou City, Jiangdu, Jiangsu 225200, China
【Abstract】Objective:To investigate the effect of zidovudine and lamivudine tablets combined with tenofovir and efavirenz in the treatment of AIDS.Methods:150 AIDS patients admitted to our hospital from January 2019 to December 2021 were selected and divided into groups according to the random table.The control group (n=75) was treated with zidovudine and lamivudine tablets and nevirapine ......
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