【摘要】目的：探讨子宫内膜癌中错配修复蛋白(MSH2、MLH1、MSH6、PMS2)的表达情况与表达组在各临床病理特征中相关差异的可能性。方法：收集2019年1月—2022年8月在本院行诊刮及手术治疗的子宫内膜癌患者，进行错配修复基因的免疫组化染色，分析患者特征与错配修复(MMR)蛋白的关系。结果：子宫内膜癌中MMR蛋白表达缺失14例，缺失率为16.67%(14/84)，dMMR组与pMMR组在浸润深度、分化程度、组织学类型、FIGO分期等临床病理特征中比较无统计学差异(P>0.05)。结论：MMR表达缺失与子宫内膜癌患者临床特征的关系不大，仅通过检测MMR表达情况无法准确筛查子宫内膜癌。

    【关键词】错配修复蛋白；子宫内膜癌；免疫组化检测

    基金项目：廊坊市科技局自筹经费课题项目《错配修复基因在子宫内膜癌中的表达及其与子宫内膜癌临床病理特征、预后关系的研究》(2020013103)

    The expression of mismatch repair (MMR) protein in patients with endometrial cancer

    YUAN Fengxia， SHI Rui， SUN Xuesong， CHEN Guizhou， AN Ziyu

    Department of pathology， Xianghe people’s hospital， Langfang City， Hebei， Langfang， Hebei 065400， China

    【Abstract】Objective：To investigate the expression of mismatch repair proteins (MSH2，MLH1，MSH6，PMS2) in endometrial carcinoma and the possibility of the relevant differences between the expression groups in various clinicopathological features.Methods：Patients with endometrial cancer who underwent curettage and surgical treatment in our hospital from January 2019 to August 2022 were collected for immunohistochemical staining of mismatch repair genes ......