【摘要】目的：探讨以乙酰半胱氨酸联合布地奈德雾化吸入对小儿肺炎疗效及肺功能影响。方法：选取本院收治的80例肺炎患儿，随机分成观察组(n=40)、对照组(n=40)。入院的两组患儿均抗感染、止咳化痰以及吸氧支持，在此基础上对照组吸入布地奈德混悬液，观察组则是联合雾化吸入乙酰半胱氨酸+布地奈德。两组均是治疗7d，对比两组的临床疗效，治疗前后的肺功能与不良反应情况。结果：临床疗效对比，观察组比对照组总有效率高，95.00%vs77.50%，对比差异显著(P<0.05)；两组患儿治疗7d的肺功能指标较治疗前提高，而观察组患儿治疗7d的FEV1(2.01±0.45)L、FVC(2.96±0.51)L、PEF(2.85±0.46)L/s指标水平均高于对照组(P<0.05)。对于组间不良反应无显著差异，2.50%vs5.00%(P>0.05)。结论：小儿肺炎采取乙酰半胱氨酸结合布地奈德联合雾化吸入可取得更好的效果，有助于提高患儿肺功能，并且在治疗期间不良反应少，是值得推广的治疗方案。

    【关键词】小儿肺炎；乙酰半胱氨酸；布地奈德；雾化吸入；临床疗效；肺功能

    Clinical efficacy of acetylcysteine combined with budesonide nebulized inhalation in the treatment of pediatric pneumonia and its effect on lung function

    Ma Xiaoli

    Department of Pediatrics， Zhangjiachuan Hui Autonomous County Maternal and Child Health Hospital， Tianshui 741500， Gansu， China

    【Abstract】Objective： To investigate the effect of acetylcysteine combined with budesonide nebulized inhalation on the efficacy and lung function of pediatric pneumonia. Methods： A total of 80 children with pneumonia admitted to our hospital were randomly divided into observation group (n=40) and control group (n=40). The two groups of children admitted to the hospital were anti-infection ......