【摘要】目的：研究HBV母婴传播影响因素及乙肝高危儿免疫预防的措施探讨。方法：2019年1月—2023年12月，纳入200例乙肝孕妇及其200例乙肝高危儿，分析HBV母婴传播影响因素及乙肝高危儿免疫预防。结果：本研究中通过对单因素分析，发现影响HBV母婴传播的因素较多，包括母体HBsAg阳性和孕期母体HBV-DNA拷贝量，差异有统计学意义(P<0.05)；低体重儿、早产儿、剖宫产、母乳喂养及孕期注射HBIG不是HBV母婴传播的影响因素，差异无统计学意义(P>0.05)。结论：影响HBV母婴传播的因素较多，针对乙肝高危儿采取免疫抑制，可以提升新生儿长期对于乙型肝炎病毒感染的免疫力。

    【关键词】母体感染；乙型肝炎病毒；新生儿；免疫预防

    Clinical analysis of influencing factors of mother to child transmission of HBV and immune prevention for high-risk infants with hepatitis B

    XU Xiaohong1， XU Haiyan2

    1.Disease Prevention and Control Center， Hai’an， Hai’an， Jiangsu 226600， China； 2.Hai’an Maternal and Child Health Care and Family Planning Service Center， Hai’an， Jiangsu 226600， China

    【Abstract】Objective：To study the influencing factors of mother to child transmission of HBV and explore the measures of immune prevention for high-risk infants with hepatitis B.Methods：From January 2019 to December 2023，200 pregnant women with hepatitis B and 200 high-risk infants with hepatitis B were included to analyze the factors affecting mother-to-child transmission of HBV and immunization prevention of high-risk infants with hepatitis B.Results：In this study ......