【摘要】目的：通过对妊娠梅毒患者及其配偶血清学随访结果进行分析，提出具体的临床防治措施。方法：选取2019年1月—2023年12月期间在本院产检和分娩诊断为梅毒的孕产妇为研究对象，共133例梅毒孕产妇，以《性传播疾病临床诊疗指南》为主要依据对梅毒患者进行规范化治疗与随访。对孕妇梅毒感染情况检测结果、孕妇及其配偶梅毒治疗后梅毒血清学试验阳性率进行分析。结果：(1)对梅毒螺旋体颗粒凝集试验(TPPA)、分期情况、传播途径3个方面的数据进行整理分析，结果显示：TPPA结果均为阳性(100.00%)；其中，一期梅毒仅4例(占3.01%)、其余均为隐性梅毒(占96.99%)；性传播途径99例(占74.44%)，为主要传播途径，不详31例(占23.31%)、父母感染2例(占1.50%)、血液感染1例(占0.75%)；(2)孕产妇配偶检测96例，检测率为72.18%，检测当中阳性24例，感染率为25.00%，经过跟踪随访后查出配偶新增12例阳性；(3)梅毒患者接受规范化治疗后，孕妇梅毒血清学试验阳性例数变为4例(3.01%)；配偶梅毒血清学试验阳性例数变为1例(1.04%)。结论：对孕期女性及其配偶而言，应该强化梅毒血清学检测，并注重对梅毒阳性孕妇及其配偶/性伴侣进行关于梅毒知识的宣教工作，采取规范化的治疗措施与随访方案，从而有效阻断梅毒的传播，将对围产儿的伤害降至最低。

    【关键词】妊娠；梅毒患者；血清学检查；梅毒螺旋体颗粒凝集试验(TPPA)；传播途径

    Analysis of serological follow-up results of pregnant syphilis patients and their spouses

    CHEN Jinping

    The Second Affiliated Hospital of Guangdong Medical University， Zhanjiang， Guangdong 524000， China

    【Abstract】Objective：To analyze the serological follow-up results of pregnant syphilis patients and their spouses and propose specific clinical prevention and treatment measures.Methods：A total of 133 pregnant and postpartum women diagnosed with syphilis during prenatal and delivery examinations in our hospital from January 2019 to December 2023 were selected as the research subjects. Standardized treatment and follow-up were conducted on syphilis patients based on the "Clinical Diagnosis and Treatment Guidelines for Sexually Transmitted Diseases".The test results of syphilis infection in pregnant women and the positive rate of syphilis serological tests after syphilis treatment for pregnant women and their spouses were analyzed.Results：(1)The data of Treponema pallidum particle agglutination test (TPPA) ......