【摘要】目的：探讨糖皮质激素联合免疫抑制剂治疗甲状腺相关性突眼的疗效。方法：纳入2019年10月—2022年10月期间的80例甲状腺相关性突眼患者，随机将其分为观察组40例和对照组40例，对照组给予常规治疗、甲泼尼龙联合吗替麦考酚酯冲击治疗，观察组在对照组的基础上于间隔期给予曲安奈德局部注射。均治疗3～6个疗程。比较两组总有效率、不良反应发生率、甲状腺功能恢复时间和治疗前后的甲状腺体积、突眼度以及免疫功能指标。结果：观察组总有效率(92.50%)高于对照组(75.00%)，P<0.05。治疗后，观察组CD3+及CD8+低于对照组，CD4+/CD8+高于对照组，P<0.05。观察组甲状腺功能恢复时间早于对照组，P<0.05。治疗后，观察组甲状腺体积小于对照组，突眼度低于对照组，P<0.05。两组不良反应发生率比较差异不大，P>0.05。结论：糖皮质激素联合免疫抑制剂治疗甲状腺相关性突眼能取得较单独使用糖皮质激素更加理想的效果，可以有效控制甲状腺的体积，降低突眼度，调节免疫功能，且这种用药方案具有较高的安全性。

    【关键词】甲状腺相关性突眼；糖皮质激素；免疫抑制剂

    Clinical efficacy observation of glucocorticoid combined with immunosuppressive agents in the treatment of thyroid associated exophthalmos

    ZHANG Haibin

    Longnan First People’s Hospital， Longnan， Gansu 746000， China

    【Abstract】Objective：To explore the efficacy of glucocorticoids combined with immunosuppressants in the treatment of thyroid associated exophthalmos.Methods：80 patients with thyroid associated exophthalmos from October 2019 to October 2022 were included and randomly divided into the observation group of 40 cases and the control group of 40 cases.The control group received routine treatment and methylprednisolone combined with mycophenolate mofetil pulse therapy ......