【摘要】目的：探讨雾化吸入布地奈德联合N-乙酰半胱氨酸佐治重症儿童肺炎支原体肺炎临床疗效。方法：根据雾化吸入的药物不同，随机将230例SMPP患儿分为三组，三组患儿在综合对症治疗基础上给予不同雾化吸入方案，疗程共14d，比较三组临床疗效、热退时间、啰音消失时间和咳嗽消失时间。结果：①B组治疗总有效率为93.59%，高于A组(83.10%)和C组(81.48%)，差异有统计学意义(P<0.05)；②B组热退时间为(4.01±1.83)d，短于A组[(5.25±2.17)d]天和C组[(5.40±2.14)d]，差异显著(P<0.05)；③B组啰音消失时间为(4.57±2.05)d，短于A组[(5.77±2.21)d]和C组[(5.74±2.05)d]，差异显著(P<0.05)；④B组咳嗽消失时间为(5.08±2.02)d，短于A组[(6.13±3.08)d]和C组[(6.11±3.29)d]，差异显著(P<0.05)。结论：雾化吸入布地奈德联合N-乙酰半胱氨酸佐治SMPP能够提高治疗效率，缩短病程，改善预后。

    【关键词】重症肺炎支原体肺炎；布地奈德；N-乙酰半胱氨酸；雾化吸入

    基金项目：北京医卫健康公益基金会项目《布地奈德联合乙酰半胱氨酸雾化吸入佐治儿童重症肺炎支原体肺炎临床疗效研究》(B20330AN)

    Observation on the clinical effect of nebulization budesonide combined with N-acetylcysteine for adjuvant treatment on severe mycoplasma pneumoniae pneumonia in children

    FENG Xianzhen， QIU Ling， LI Mengshuang， LI Jincheng

    The Third People’s Hospital of Linyi， Linyi， Shandong 276023， China

    【Abstract】Objective：To investigate the clinical effect of nebulization budesonide combined with N-acetylcysteine for adjuvant treatment on severe mycoplasma pneumoniae pneumonia in children.Methods：230 children with SMPP were randomly divided into three groups according to different drugs inhaled by atomization.On the basis of comprehensive symptomatic treatment ......