【摘要】目的：探究肿瘤标志物与凝血4项在乙肝相关肝癌疾病中的诊断价值。方法：择取南京大学医学院附属盐城第一医院(盐城市第一人民医院)54例乙肝相关肝癌患者(2021年1月—2023年12月)作为观察组，同期选择70名健康受试者作为对照组，对两组研究对象进行凝血4项与肿瘤标志物检测，分析诊断效能。结果：观察组凝血酶原时间(prothrombin time，PT)、活化部分凝血活酶时间(activated partial thromboplastin time ，APTT)及凝血酶时间(thrombin time，TT)均长于对照组，肿瘤标志物水平高于对照组，纤维蛋白原(fibrinogen，Fib)水平低于对照组(P<0.05)；联合检测的曲线下面积(area under the curve，AUC)高于单一检测。结论：肿瘤标志物可准确反映肝癌疾病进展程度，同时凝血功能指标能够反映患者机体凝血系统功能，联合检测的应用价值要高于单一检测，可推广。

    【关键词】乙肝相关肝癌；肿瘤标志物；凝血4项；诊断效能

    Significance of tumor markers and four tests of coagulation in the diagnosis of hepatitis Brelated liver cancer

    MAO Jing

    Department of LaboratorS4cIQlXQsiiqIxJlkzFjlH0j+gLzkQtFdH30QfC1s7Y=y Medicine，Yancheng First Hospital Affiliated to Nanjing University School of Medicine (Yancheng First People’s Hospital)， Yancheng， Jiangsu 224000， China

    【Abstract】Objective：To explore the diagnostic value of tumor markers and four items of blood coagulation in hepatitis B related liver cancer.Methods：54 patients with hepatitis Brelated hepatocellular carcinoma (from January 2021to December 2023) from Yancheng No.1 Hospital affiliated to Nanjing University School of Medicine (Yancheng No.1 People’s Hospital) were selected as the observation group ......