【摘要】创伤性脑损伤(TBI)是全球范围内一个重要的健康问题。铁死亡是一种新近发现的细胞死亡方式，被证实参与TBI后继发性神经元死亡，可以导致TBI后神经退行性和神经功能障碍。核因子E2相关因子2(nuclear factor E2 related factor 2，Nrf2)不仅是抗铁死亡基因的重要转录调节因子，还是细胞抗氧化反应的关键调节因子，可通过缓解氧化应激反应和游离铁的积累来减轻创伤性脑损伤造成的神经损伤，从而抑制创伤性脑损伤后铁死亡。本文通过分析创伤性脑损伤、铁死亡和Nrf2三者之间的联系，就Nrf2对创伤性脑损伤后神经细胞铁死亡的保护作用作一综述。

    【关键词】创伤性脑损伤；核因子E2相关因子2；铁死亡

    Research progress of Nrf2 inhibiting ferroptosis after traumatic brain injury

    LIANG Baiwei1， MA Zhuangzhuang1， ZHANG Mengzhu1， YAO Yewei1， YAN Baobao2

    1.College of Basic Medicine and Forensic Medicine， Henan University of Science and Technology， Luoyang， Henan 471023， China； 2.Baoding No.1 Central Hospital， Baoding， Hebei 071000， China

    【Abstract】Traumatic brain injury (TBI) is an important health issue on a global scale.Ferroptosis is a newly discovered mode of cell death that has been confirmed to be involved in secondary neuronal death after TBI，which can lead to neurodegeneration and neurological dysfunction after TBI.Nuclear factor E2 related factor 2 (Nrf2) is not only an important transcriptional regulator of anti ferroptosis genes ......