郭敏 杨芮 胡良伟 晏子友

    摘要：心脏损害是慢性肾脏病进展过程中常见并发症之一，大量研究表明线粒体自噬能干预慢性肾脏病心脏损害的病程。线粒体自噬是当今医学调控慢性肾脏病心脏损害重要靶点及研究课题。慢性肾脏病患者体内毒素代谢异常，同时心肾两脏富含线粒体，慢性肾脏病后期尿毒症毒素内积，线粒体凋亡及受损线粒体释放出的大量有害物质的过程与中医浊毒内生相似。通过从慢性肾脏病、线粒体自噬与浊毒的关系，慢性肾脏病并发心脏损害的浊毒理论，浊毒、线粒体自噬与心脏损害的联系，浊毒-线粒体自噬-慢性肾脏病并发心脏损害的形成，中医药祛浊毒理论干预线粒体自噬治疗慢性肾脏病心脏损害来论述。

    关键词：慢性肾脏病；心脏损害；浊毒；线粒体自噬；中医药治疗

    中图分类号：R692

    文献标志码：A

    文章编号：1007-2349(2024)01-0018-05

    Discussion on Cardiac Damage in Chronic Kidney Disease Based

    on “Turbid Toxin-Mitochondrial Autophagy”

    GUO Min，Yang Rui，HU Liang-wei，YAN Zi-you

    (1. Jiangxi University of Traditional Chinese Medicine，Nanchang 330006，China;

    2. The Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine，Nanchang 330006，China)

    【Abstract】Cardiac damage is one of the common complications in the progression of chronic kidney disease. A large number of studies have shown that mitochondrial autophagy can interfere with the course of cardiac damage in chronic kidney disease. Mitochondrial autophagy is an important target and research topic for regulating heart damage in chronic kidney disease. In patients with chronic kidney disease ......