Research Progress on the Regulation of P53 by Traditional Chinese Medicine in the Treatment of Diabetic Nephropathy

    JIN Rui1，ZHOUFu-rong1，BAO Yun2

    (1.InnerMongolia Medical University，HohhotO1ooio，China; 2.TheAffiliated Hospital of InnerMongoliaMedical University，Hohhot Oiooio，China)

    【Abstract】Diabetic kidney disease (DKD) is one of the common and serious microvascular complications of diabetes and has become a major factor in end -stage renal diseases worldwide.Currently，the number of DKD patients worldwide accounts for 8%-10% of the total world population. It is estimated that this number will increase to 592 millon by2O35.The incidencerateof DKDinChina isalso gradually increasing.Due to the complex pathogenesis of DKD，it alsoadds many dificulties to clinical treatment.P53，as an important tumorsuppressor gene，has been confirmed to playa significant role in the occurrence and development of diabetic nephropathy.In recent years，an increasing number of studies have focusedon the treatment of diabetic nephropathy by traditional Chinese medicine through regulating P53 ......