丁美林 宗阳 徐玲玲 周建华 蒋勇 江建国

    【摘要】目的：优选消痔洗剂的提取工艺，为该制剂制备工艺提供参考。方法：采用挥发油测定法，提取鱼腥草挥发油，通过单因素考察试验，优选鱼腥草提取工艺。以君药中盐酸小檗碱的含量、干膏率的综合评分为评价指标，采用正交试验法，考察水提取最佳工艺。结果：鱼腥草挥发油最佳提取工艺为：加入14倍量的水，浸泡2h，提取5h。水提取最佳工艺为：加入12倍量的水，浸泡1.5h，提取1.5h，煎煮2次。结论：该提取工艺稳定、合理、可行，适用于消痔洗剂的制备。

    【关键词】消痔洗剂;挥发油;盐酸小檗碱;正交试验

    【中图分类号】R94【文献标志码】 A【文章编号】1007-8517(2021)18-0042-05

    Study on Extraction Technology of Xiaozhi LotionDING Meilin1ZONG Yang2XU Lingling3ZHOU Jianhua1JIANG Yong1JIANG Jianguo1*

    1.Rudong County Hospital of Traditional Chinese Medicine，Rudong 226400，China;

    2.Suzhou Hospital of Traditional Chinese Medicine，Suzhou 215000，China;

    3.Shanghai University of Traditional Chinese Medicine，Shanghai 200120，ChinaAbstract：Objective To optimize the extraction process of Xiaozhi Lotion，and to provide reference for the preparation process of this preparation.Methods The volatile oil of Houttuynia cordata was extracted by the determination of volatile oil ......