黎嘉茗 张万青 刘潇潇

    【摘 要】目的：建立孕康口服液中驴皮源及牛皮源成分的专属性检测方法。方法：选用胰蛋白酶技术对孕康口服液中胶类成分进行处理，利用超高效液相色谱-三重四极杆质谱(UPLC-QQQ-MS)对驴皮源及牛皮源成分的专属性特征分子离子峰进行检测。结果：10批样品均检出驴皮源成分的特征离子峰，并且均未检出牛皮源成分的特征离子峰。结论：该方法操作简便、准确、快速，灵敏度高，可用于孕康口服液中驴皮源的鉴别及牛皮源的检查。

    【关键词】超高效液相色谱-三重四极杆质谱；孕康口服液；驴皮源；牛皮源；特征肽

    【中图分类号】

    R284.1 【文献标志码】 A【文章编号】1007-8517(2024)06-0043-04

    DOI：10.3969/j.issn.1007-8517.2024.06.zgmzmjyyzz202406010

    Determination of Donkey Skin and Bovine Skin in Yunkang Oral Liquid by UPLC-QQQ-MS

    LI Jiaming ZHANG Wanqing LIU Xiaoxiao^*

    Guangdong Institute for Drug Control，Guangzhou 510663，China

    Abstract：Objective To establish a specific method for determination of donkey skin and bovine skin in Yunkang oral liquid.Methods The trypsin technology was used to treat the gum components in Yunkang oral liquid ......