固体脂质纳米粒给药新载体的研究进展
(广东药学院，广东省药物新剂型重点实验室，广东,广州，510006)【摘要】固体脂质纳米粒是近年来很受重视的一种新型药物传递载体，它综合了传统胶体给药系统如乳剂、脂质体及聚合物纳米粒等的优点，具有靶向、控释、提高药物稳定性、毒性小、可大批量生产等特性，可供多途径给药。本文就近年来固体脂质纳米粒的特性、制备方法、药物释放、给药途径以及发展前景作一简要综述。
【关键词】固体脂质纳米粒；载体；给药途径
【中图分类号】R965.1【文献标识码】A【文章编号】1007-8517(2009)02-0007-04
Research advances on Solid lipid nanoparticles as new drug carrier
Chen Tongkai, Li Yuan, Lin Huaqing
(Guangdong Pharmaceutical University, Guangzhou provincial key laboratory of advanced drug delivery, Guangzhou, 510006)【Abstract】In recent years, the SLNshave been reported as potential drug carrier systems. They offer the possibility of controlled drug release and drug targeting and produce protection of incorporated active compounds against degradation, which combine the advantages of other traditional collodial systems(i.e. microemulsions, liposomes and polymeric nanoparticles). SLNs formulations for various application routes have been developed and thoroughly characterized in vitro and in vivo. This paper was focused on characterization of SLNs suspensions, the preparation, application routes and development prospect.【Keywords】Solid lipid nanoparticles(SLNs)； Carrier； Administration routes ......
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