黄天明，莫发荣，罗国容

    ·专题研究·

    【编者按】原发性肝癌(肝癌)是我国常见恶性肿瘤之一，我国每年约14万人死于肝癌。由于肝癌起病隐匿，早期没有症状，就诊时多属晚期，患者生存期一般为3～6个月，故早期诊断是提高肝癌患者疗效、改善患者预后的关键。本期“专题研究”主要报道了肝癌自发性消退这一“有趣”现象，以更深入更全面地了解肝癌流行病学特点；同时报道了近年来研究较热的硫氧还蛋白(TRX)、高尔基体糖蛋白73(GP73)、α-L-岩藻糖苷酶(AFU)等对肝癌的诊断价值，为临床上寻找更为有效和准确的肝癌肿瘤标志物提供参考。

    肝细胞癌自发消退的流行病学研究

    黄天明，莫发荣，罗国容

    目的分析肝细胞癌(HCC)自发消退的发生规律。方法对MEDLINE进行检索，获取自1982年以来HCC自发消退的病例85例，对所得病例资料进行分析，并与HCC的流行病学特点进行比较。结果HCC自发消退发生概率可能比之前估计的要高，其多发生于酒精所致的HCC患者，而与患者的种族、年龄、性别及肿瘤的分化程度和进展程度可能无明显关联；导致HCC自发消退的最可能的原因为免疫因素。结论HCC自发消退的发生可能是外界微环境或条件改变的结果，而与肿瘤细胞自身的生物学属性可能无关；深入探讨其发生机制有可能开辟HCC治疗的新方向。

    癌，肝细胞；肿瘤消退，自行性；流行病学；免疫

    R 735.7【文献标识码】 Adoi：10.3969/j.issn.1007-9572.2013.05.039

    黄天明，莫发荣，罗国容.肝细胞癌自发消退的流行病学研究[J].中国全科医学，2013，16(5)：1575-1577.[www.chinagp.net]

    EpidemiologicalAnalysisofSpontaneousRegressionofHepatocellularCarcinoma

    HUANG Tian-ming，MO Fa-rong,LUO Guo-rong.

    Department of Histology and Embryology of Guangxi Medical University,Nanning 530021，China

    ObjectiveTo investigate the regularity of spontaneous regression of hepatocellular carcinoma(HCC).MethodsA total of 85 cases of HCC spontaneous regression of HCC were obtained through searching in MEDLINE.All clinical data were analyzed and compared with HCC epidemiological characteristics.ResultsThe probability of HCC spontaneous regression incidence was higher than previously estimated.It mostly occurred in alcohol-caused HCC patients,not obviously correlated with patients′ kind,age,gender,tumor differentiation and its progression.The most probable cause leading HCC spontaneous regression were immune factors.ConclusionSpontaneous regression of HCC maybe be a result of changes of external micro-environment or conditions,not correlated with the biological properties of tumor cells.Deep exploration for its mechanism may open up an entirely new approach to HCC direction. ......