·论著·

    Vaspin与2型糖尿病肾病的相关性研究

    刘平，刘波，门晓彦，王迪，李莉，刘博伟，杨艳玲

    作者单位：066000河北省秦皇岛市第三医院内分泌科(刘平)；秦皇岛市第一医院内分泌科(刘波，王迪，刘博伟，杨艳玲)；秦皇岛市海港医院内分泌科(门晓彦)；秦皇岛市疾病预防控制中心公共卫生科(李莉)

    通信作者：刘波，066000河北省秦皇岛市第一医院内分泌科；E-mail:lylybobo@163.com

    【摘要】目的探讨2型糖尿病(T2DM)患者血清中脂肪特异性丝氨酸蛋白酶抑制剂Vaspin与糖尿病肾病(DN)的关系。方法选取2013年11月—2014年2月秦皇岛市第三医院内分泌科住院的T2DM患者94例，根据24 h尿清蛋白排泄率(UAER)分为糖尿病(DM)组(UAER≤20 μg/min)和DN组(UAER>20 μg /min)。选取同期该院50例健康体检者为对照组。测定血清Vaspin及空腹血糖(FBG)、空腹胰岛素(FINS)、血脂、糖化血红蛋白(HbA1c)、尿素氮(BUN)、肌酐(Cr)水平，采用稳态模型评估胰岛素抵抗指数(HOMA-IR)，分析血清Vaspin与各指标之间的相关性，并对T2DM发生DN的影响因素进行Logistic回归分析。结果DN组血清Vaspin水平低于DM组、高于对照组，DM组高于对照组，差异均有统计学意义(P20 μg /min).We also enrolled 50 healthy controls from the hospital in the same period as control group.The levels of Vaspin,FBG,FINS,blood fat,HbA1c,BUN and Cr were determined.Hemostasis model was employed to evaluate HOMA-IR,and the correlations between Vaspin and other indicators were investigated.Logistic regression analysis was also conducted to investigate the influencing factors for DN in T2DM patients.ResultsFor Vaspin level,DN group was lower (P20 μg /min) ......