【摘要】 儿茶酚胺敏感性室性心动过速是一种潜在的致死性心脏通道病，其特点是在运动或紧张的情况下持续室性心动过速，多发病于青少年时期，临床表现可为头晕、心悸甚至猝死。儿茶酚胺敏感性室性心动过速属于常染色体遗传，发病罕见，与编码钙通道的基因突变有关，该突变可导致舒张期心肌细胞肌质网的钙泄露，导致去极化后延迟并触发活性，从而诱发心律失常。目前儿茶酚胺敏感性室性心动过速的治疗方法主要包括生活方式的改变、药物、植入式心脏复律除颤器、左侧心交感神经切除术手术以及基因治疗，其中β受体阻滞剂是目前治疗的基石。

    【关键词】 心动过速，室性；儿茶酚胺类；基因；治疗；综述

    【中图分类号】 R 541.7 【文献标识码】 A

    Research Progress of Catecholaminergic Polymorphic Ventricular Tachycardia MAI Fei1，ZHOU Rong2

    1.Shanxi Medical University Graduate School，Taiyuan 030000，China

    2.Department of Cardiology，the Second Hospital of Shanxi Medical University，Taiyuan 030000，China

    【Abstract】 Catecholaminergic polymorphic ventricular tachycardia is a potentially fatal cardiac channel disease. It is characterized by sustained ventricular tachycardia during exercise or stress. It occurs frequently in adolescence. The clinical manifestations may be dizziness，palpitation or even sudden death. It belongs to autosomal inheritance and is rare. It is related to a mutation in the gene encoding calcium channel，which can lead to calcium leakage in the sarcoplasmic reticulum of diastolic cardiomyocytes ......