【摘要】 目的 探讨不同溶栓时间窗重组组织型纤溶酶原激活剂(rt-PA)治疗缺血性脑卒中的疗效。方法 选取2018年1月至2021年6月扬中市人民医院收治的符合静脉溶栓条件的急性缺血性脑卒中(AIS)患者120例，根据发病至就诊时间分为A组(发病至就诊时间lt;3 h)，B组(发病至就诊时间3.0～4.5 h)，均接受rt-PA静脉溶栓治疗。采用美国国立卫生研究院量表(NIHSS)和改良Rankin量表(mRS)评估患者治疗效果，观察治疗期间不良反应。结果 A组患者总有效率〔93.3%(42/45)〕与B组〔92.0%(69/75)〕比较，差异无统计学意义(χ2=0.072，P=0.788)。溶栓后两组NIHSS评分低于溶栓前(Plt;0.05)，但两组间差异无统计学意义(Pgt;0.05)。两组患者mRS评分比较，差异无统计学意义(Pgt;0.05)。结论 不同时间窗rt-PA静脉治疗缺血性卒中患者的临床疗效相当，均具有较好效果，均能改善患者的神经功能及预后，无明显不良反应。

    【关键词】 缺血性脑卒中；重组组织型纤溶酶原激活剂；时间窗；治疗结果

    【中图分类号】 R 743.3 【文献标识码】 A

    Comparison of the Efficacy of rt-PA Administration in Different Time windows in the Treatment of Ischemic Stroke YAO Lei1，LU Ping2*

    1.Yangzhong People's Hospital，Yangzhong 212200，China

    2.Affiliated Hospital of Jiangsu University，Zhenjiang 212200，China

    *Corresponding author：LU Ping，research direction：emergency treatment

    【Abstract】 Objective To investigate the efficacy of rt-PA administration in different time windows in the treatment of ischemic stroke. Methods 120 AIS patients who met the conditions of intravenous thrombolysis in Yangzhong People's Hospital from January 2018 to June 2021 divided into group A(onset to treatment time lt;3 h)and group B(onset to treatment time 3-4.5 h). All patients received rt-PA intravenous thrombolysis. The therapeutic effects were evaluated by National Institutes of Health Scale(NIHSS)and Modified Rankin Scale(mRS). Results The total effective rate of patients in group A〔93.3%(42/45)〕compared with group B〔92.0%(69/75)〕showed no significant difference (χ2=0.072 ......