张柠 樊世明

    【摘要】 高海拔地区低压、低氧环境致人体内代谢水平发生一系列变化，其特殊环境使体内氧化应激水平、同型半胱氨酸水平升高，从而损伤血管内皮细胞，高同型半胱氨酸血症会加剧氧化应激，进一步加重对血管内皮的损伤，加速高血压的发生、发展。在传统降压药治疗的基础上联合使用抗氧化药物可为高海拔地区H型高血压的治疗提供新方向。本文主要就高海拔地区H型高血压患者血管内皮功能与氧化应激的关系进行综述，探索其发病机制及可能的治疗方法。

    【关键词】 高血压；H型高血压；高同型半胱氨酸血症；血管内皮细胞

    【中图分类号】 R 544.1 【文献标识码】 A DOI：10.12114/j.issn.1007-9572.2024.0040

    Research Progress on Vascular Endothelial Function and Oxidative Stress in Patients with H-type Hypertension at High Altitudes

    ZHANG Ning1，FAN Shiming2*

    1.Graduate School of Qinghai University，Xining 810000，China

    2.Affiliated Hospital of Qinghai University，Xining 810000，China

    *Corresponding author：FAN Shiming，Chief physician/Professor；E-mail：13639786140@163.com

    【Abstract】 The low-pressure and low-oxygen environment at high altitude causes a series of changes in the metabolic level in the human body. The high altitude environment increases the level of oxidative stress and homocysteine in the body，which damages vascular endothelial cells. Hyperhomocysteinemia exacerbates oxidative stress，further aggravates the damage to the vascular endothelium ......