【摘要】 儿童肥胖发病率逐年升高，已成为全球公共卫生领域面临的新挑战。研究表明，生命早期肠道菌群的改变可通过影响机体营养吸收与代谢、诱发炎症反应及肠-脑轴的调控等机制导致儿童肥胖的发展。目前，双歧杆菌和嗜黏蛋白阿克曼菌被发现能够降低体内脂肪含量、发挥抗炎特性及增强肠道屏障功能，而普雷沃氏菌则与膳食纤维诱导的个体糖代谢改善密切相关。针对具有改善机体糖脂代谢作用的部分肠道菌群进行转化应用，将有助于儿童肥胖的早期防治。本文主要介绍了生命早期肠道菌群的组成变化对儿童肥胖的影响以及肠道菌群参与肥胖发病的机制，重点阐述了短链脂肪酸在调节肠道菌群和改善肥胖中的最新研究进展，旨在为从肠道菌群视角干预儿童肥胖的发展提供理论依据。

    【关键词】 肠道菌群；儿童肥胖；机制；短链脂肪酸

    【中图分类号】 R 378.2 R 725.892.5 【文献标识码】 A DOI：10.12114/j.issn.1007-9572.2023.0809

    Intestinal Flora：an Important Participant in Childhood Obesity

    LUO Yu1，2，LUO Dan2，3，TANG Binzhi1，2，3*

    1.Clinical College of University of Electronic Science and Technology of China，Chengdu 610054，China

    2.Department of Pediatrics，Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital，Chengdu 610072，China

    3.School of Medicine and Life Science of Chengdu University of Traditional Chinese Medicine，Chengdu 610075，China

    *Corresponding author：TANG Binzhi，Associate chief physician；E-mail：tangbinzhi@uestc.edu.cn

    【Abstract】 The increasing incidence of childhood obesity has emerged as a novel challenge in the realm of global public health. Studies have demonstrated that alterations in the composition of intestinal flora during the early stages of life contribute to the development of obesity by influencing nutrient absorption and metabolism ......