【摘要】 糖尿病(DM)高血糖病理状态是导致男性生精障碍的重要因素之一，下丘脑-垂体-性腺(HPG)轴是人体全身植物性功能、神经内分泌网络的重要枢纽，生理上主导人类生殖及生长发育，病理上又可受到DM高血糖病理状态的影响，是2型糖尿病(T2DM)生精障碍发生、发展过程中的关键机制之一，肾虚是生精障碍和T2DM共同的病因病机。肾藏精所体现的“主生殖、生髓充脑”功能与HPG轴功能相似，补肾法对HPG轴功能具有调节改善作用，为补肾法治疗T2DM生精障碍奠定理论基础。补肾经典方剂在治疗DM与生精障碍上相得益彰，为临床以补肾法防治T2DM生精障碍之不育症提供了思路和方法。

    【关键词】 下丘脑-垂体系统；糖尿病，2型；生精障碍；补肾；理论探讨

    【中图分类号】 R 322.54 R 587.1 【文献标识码】 A DOI：10.12114/j.issn.1007-9572.2023.0644

    The Idea of Kidney Tonifying Therapy for Spermatogenesis Disorder in Type 2 Diabetes Mellitus Based on the Hypothalamic-pituitary-gonadal Axis

    LU Wei1，2，YANG Yunsong1，LIN Lianmei1，LIU Qiong1，ZHAO Min3，LI Jia2，4，LIANG Fengxia2，4，WU Song2，4*

    1.Clinical College of Chinese Medicine，Hubei University of Chinese Medicine，Wuhan 430061，China

    2.Hubei Provincial Collaborative Innovation Center of Preventive Treatment by Acupuncture and Moxibustion，Wuhan 430061，China

    3.School of Basic Medicine，Hubei University of Chinese Medicine，Wuhan 430065，China

    4.College of Acupuncture and Orthopedics，Hubei University of Traditional Chinese Medicine，Wuhan 430061，China

    *Corresponding author：WU Song ......