内皮细胞损伤及其功能障碍在动脉粥样硬化中作用的研究进展






中图分类号】 R 543.5 【文献标识码】 ADOI:10.12114/j.issn.1007-9572.2024.0440
【Abstract】Cardiovascular disease is a prevalent condition characterized bya high incidence rate and mortality. Atherosclerosis(AS)servesastheunderlying pathologicalmechanism fornumerous cardiovasculardiseases,primarilymarked bylipidaccumulationand plaque formation withinarterial wals,therebyimpactingtissueororgan ischemiaornecrosis.This comprehensivearticledelvesintothepivotalroleofendothelialcells(ECs)inatheroslerosis,elucidatingtheirmechanismsof injuryanddysfunction,aswellastheir interactions withmacrophagesandvascularsmoothmusclecells(VSMCs)duringthis proces.ThefindingspresentedhereinunderscorethecriticalinvolvementofECsinASpathogenesis ......
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