小剂量普萘洛尔治疗婴幼儿血管瘤的临床观察(1)
 |
| 第1页 |
参见附件(2351KB，3页)。
[摘要]目的：探讨小剂量普萘洛尔治疗婴幼儿血管瘤的疗效及安全性。方法：收集增生期婴幼儿血管瘤23例(男6例，女17例)，口服普萘洛尔0.5～0.75 mg/(kg·d)，疗程1～9个月，并进行疗效评定和安全性评价。结果：疗效评定：优6例(26.1%)，良9例(39.1%)，中等8例(34.8%)；不良反应包括：心率轻度减慢8例(34.78%)，睡眠障碍2例(8.7%)，腹泻1例(4.3%)。不良反应轻，均1周内自行消失；安全性评定：15例为安全，8例为比较安全。结论：小剂量普萘洛尔治疗婴幼儿血管瘤，疗效良好，不良反应轻，安全性较好。
[关键词]血管瘤；婴幼儿；普萘洛尔
[中图分类号]R732.2[文献标识码]A[文章编号]1008-6455(2011)10-1584-02
Clinical observations on infantile hemangiomas treated with low-dose propranolol
FENG Jin-yun1, RAO Guo-zhou2, PENG Zhen-hui3
(1.Department of Dermatology,The Children Hospital of Shenzhen, Shenzhen 518026,Guangdong,China；2.Medical Science Research Center,Stomatological Hospital,Xi'an Jiaotong University；3.Department of Dermatology, the Second Hospital of Xi'an Jiaotong University)
Abstract:ObjectiveTo explore the efficacy and safety of low-dose propranolol in the treatment of infantile hemangiomas. MethodsA total of 23 infants (6 males and 17 females) with proliferative hemangiomas were treated with propranolol. Propranolol was orally administered at 0.5 to 0.75 mg/kg/day.The total time of therapy was 1 month to 9 months.The efficacy and safety of medication was evaluated after finishing treatment. ResultsResponse to propranolol therapy was excellent in 6 patients (26.1%),good in 9 patients (39.1%), fair in 8 patients (34.8%) and none poor. Mild adverse effects were noted in 8 patients(34.8%), including heart rate gently slowing (34.8%), mild sleep disorder (8.7%) and diarrhea (4.3%).The adverse effects disappeared within one week of their occurrence, needing no special handling.Safety evaluation of therapy showed safe in 15 patients (65.2%),relative safe in 8 patients (34.8%).Conclusions Low-dose propranolol is effective and safe in the treatment for infantile hemangiomas, with only limited and mild side effects.
Key words：hemangioma；Infant；Propranolol
婴幼儿血管瘤(Infantile hemangiomas)是婴幼儿时期最常见的良性肿瘤。多数学者认为，对增长较快或影响功能和容貌的血管瘤应进行积极的干预。现有治疗血管瘤的方法有时疗效不确切，且有一定的副作用。2008年，Léauté-Labrèze等[1]首次发现普萘洛尔对血管瘤有显著的治疗效果，使得普萘洛尔成为药物治疗血管瘤的一种新选择。另据报道[2]，与白种人相比，中国人对普萘洛尔的敏感性较高、耐受性较差；这提示在使用普萘洛尔治疗中国婴幼儿血管瘤时 ......
您现在查看是摘要介绍页，详见PDF附件(2351KB，3页)。