平阳霉素诱导人血管瘤内皮细胞凋亡过程中PARP—1和Cyt—C的表达及意义(3)
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以上实验结果表明,平阳霉素诱导人血管瘤内皮细胞凋亡途径复杂,涉及多种因素,其中有线粒体凋亡相关蛋白:PARP-1及Cyt C参与。平阳霉素为治疗血管瘤的常用药物,可以在体外诱导人血管瘤内皮细胞发生凋亡,我们在实验结果中得到血管瘤内皮细胞凋亡过程中有线粒体途径参与。我们尚不知是否有其他的凋亡途径参与到血管瘤内皮细胞的凋亡。目前这方面的研究也并不完善,对于差异蛋白组中的未知蛋白的作用未能做深入研究,对这些未知蛋白在凋亡过程中发挥的作用深入研究,有助于我们深刻理解血管瘤的成因及凋亡机制,可能为血管瘤的治疗带来新的思路。
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