毛发移植联合富血小板血浆注射在雄激素性秃发患者治疗中的应用分析(1)
[摘要]目的：探讨毛发移植联合富血小板血浆注射在雄激素性秃发患者治疗中的应用价值。方法：选取2015年6月-2017年9月笔者医院接收的120例雄激素性秃发患者，随机分为两组。治疗组：70例，接受毛发移植联合富血小板血浆治疗；对照组：50例，仅接受毛发移植。毛发移植术前和毛发移植联合注射PRP治疗后(即术后12周)用数码相机记录脱发区域的毛发情况，对治疗前后脱发面积，拉发试验，毛发再生情况、皮损总面积及临床疗效进行分析。结果：两组治疗前后在脱发面积、拉发试验、毛发再生方面比较，具有显著性差异(P<0.05)，治疗后均有所改善；治疗组在减小脱发面积、改善拉发试验、提高毛发再生情况方面均优于对照组，具有统计学意义(P<0.05)，治疗组皮损总面积明显低于对照组(P<0.05)；治疗组的总有效率(87.14%)明显高于对照组(62.00%)，(P<0.05)，有统计学意义。结论：毛发移植联合富血小板血浆治疗雄激素性秃发疗效优于单独毛发移植，在临床上有很好的应用潜力。
[关键词]毛发移植；富血小板血浆；雄激素性秃发；联合治疗；毛发再生
, http://www.100md.com
[中图分类号]R758.71 [文献标志码]A [文章编号]1008-6455(2018)12-0060-03
The Value of Hair Transplantation Combined with Platelet-Rich Plasma in the Treatment of Androgen Alopecia
ZHANG Qiong-ling1，LIU Qing2，YU Yin-xia1
(1.Department of Medical Cosmetology， Minhang District Central Hospital，Shanghai 200011，China；2. Department of Reconstructive Surgery， Shanghai Ninth People's Hospital，Shanghai 201199，China)
, 百拇医药
Abstract： Objective To explore the value of hair transplantation combined with platelet-rich plasma in the treatment of androgen alopecia. Methods From June 2015 to September 2017，120 patients with androgen alopecia were selected.70 of them received hair transplantation combined with platelet-rich plasma as the treatment group.The other 50 cases received hair transplantation only as the control group.Digital cameras were used to record hair in the alopecia area before and 12 weeks after hair transplantation.The alopecia area， hair pulling test， hair regeneration， total area of skin lesion and clinical curative effect were analyzed before and after treatment. Results There were significant differences in hair loss area， hair pulling test and hair regeneration between the two groups before and after treatment (P<0.05).The treatment group was better than the control group in reducing the area of hair loss， improving the hair pulling experiment and improving the hair regeneration. The analysis had statistical significance (P<0.05).The total area of skin lesions in the treatment group was significantly lower than that in the control group (P<0.05).The total effective rate of the treatment group (87.14%) was significantly higher than that of the control group (62%) (P<0.05). Conclusion Hair transplantation combined with platelet-rich plasma therapy has good clinical potential because of hair transplantation alone.
, 百拇医药
Key words： hair transplantation； platelet-rich plasma； androgen alopecia； combined therapy；hair regeneration
雄激素性禿发是一种雄激素依赖的染色体显性遗传性疾病。表现为患者的头发密度进行性减少，并伴有头皮油腻、头屑增多、瘙痒等症状，不仅影响美观，还会影响其心理健康和社交生活[1]。目前临床上治疗雄激素性秃发常用药物为非那雄胺、米诺地尔等，虽有疗效，但可能影响患者的性功能，还可引起多毛症、过敏等不良反应，对女性患者不太适用。虽然毛发移植可有效改善外观，但治疗费用高昂[2]。富血小板血浆是高度浓缩的血小板，有助于组织修复，在溃疡、创面、骨折端愈合等治疗方面应用较多，其促进组织修复的功能已得到临床广泛认可[3]。近年来有研究发现，富血小板血浆中富含血管内皮生长因子、血小板衍生生长因子等物质，可促进毛发和毛囊的生长[4]。本研究就毛发移植联合富血小板血浆在雄激素性秃发患者治疗中的应用进行研究，现将结果报道如下。, 百拇医药(张琼玲 刘清 余银霞)
[关键词]毛发移植；富血小板血浆；雄激素性秃发；联合治疗；毛发再生
, http://www.100md.com
[中图分类号]R758.71 [文献标志码]A [文章编号]1008-6455(2018)12-0060-03
The Value of Hair Transplantation Combined with Platelet-Rich Plasma in the Treatment of Androgen Alopecia
ZHANG Qiong-ling1，LIU Qing2，YU Yin-xia1
(1.Department of Medical Cosmetology， Minhang District Central Hospital，Shanghai 200011，China；2. Department of Reconstructive Surgery， Shanghai Ninth People's Hospital，Shanghai 201199，China)
, 百拇医药
Abstract： Objective To explore the value of hair transplantation combined with platelet-rich plasma in the treatment of androgen alopecia. Methods From June 2015 to September 2017，120 patients with androgen alopecia were selected.70 of them received hair transplantation combined with platelet-rich plasma as the treatment group.The other 50 cases received hair transplantation only as the control group.Digital cameras were used to record hair in the alopecia area before and 12 weeks after hair transplantation.The alopecia area， hair pulling test， hair regeneration， total area of skin lesion and clinical curative effect were analyzed before and after treatment. Results There were significant differences in hair loss area， hair pulling test and hair regeneration between the two groups before and after treatment (P<0.05).The treatment group was better than the control group in reducing the area of hair loss， improving the hair pulling experiment and improving the hair regeneration. The analysis had statistical significance (P<0.05).The total area of skin lesions in the treatment group was significantly lower than that in the control group (P<0.05).The total effective rate of the treatment group (87.14%) was significantly higher than that of the control group (62%) (P<0.05). Conclusion Hair transplantation combined with platelet-rich plasma therapy has good clinical potential because of hair transplantation alone.
, 百拇医药
Key words： hair transplantation； platelet-rich plasma； androgen alopecia； combined therapy；hair regeneration
雄激素性禿发是一种雄激素依赖的染色体显性遗传性疾病。表现为患者的头发密度进行性减少，并伴有头皮油腻、头屑增多、瘙痒等症状，不仅影响美观，还会影响其心理健康和社交生活[1]。目前临床上治疗雄激素性秃发常用药物为非那雄胺、米诺地尔等，虽有疗效，但可能影响患者的性功能，还可引起多毛症、过敏等不良反应，对女性患者不太适用。虽然毛发移植可有效改善外观，但治疗费用高昂[2]。富血小板血浆是高度浓缩的血小板，有助于组织修复，在溃疡、创面、骨折端愈合等治疗方面应用较多，其促进组织修复的功能已得到临床广泛认可[3]。近年来有研究发现，富血小板血浆中富含血管内皮生长因子、血小板衍生生长因子等物质，可促进毛发和毛囊的生长[4]。本研究就毛发移植联合富血小板血浆在雄激素性秃发患者治疗中的应用进行研究，现将结果报道如下。, 百拇医药(张琼玲 刘清 余银霞)
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