红蓝光与5—氨基酮戊酸光动力治疗寻常性痤疮疗效比较(1)

http://www.100md.com 2018年6月15日 《中国美容医学》 2018年第12期

     [摘要]目的：比较红蓝光治疗与5-氨基酮戊酸光动力(ALA-PDT)治疗寻常性痤疮的临床疗效。方法：选择2015年1月-2017年10月在笔者科室治疗的64例寻常性痤疮患者的病例资料进行回顾性分析，按照治疗方法不同分组。对照组：32例，使用红蓝光治疗；观察组：32例，采用ALA-PDT治疗。对比两组治疗效果。结果：观察组的疗效优于对照组，两组数据比较有显著性差异，具有统计学意义(z=-2.600，P<0.05)；完成治疗后，两组患者的临床症状积分均降低，观察组患者降低的幅度大于对照组，数据差异具有统计学意义(t=25.108，P<0.05)，在治疗过程中，两组患者的各类不良反应发生比较，均无统计学意义(χ2=0.217，0.350，0.736，0.571，0.350，P>0.05)，两组患者的复发率比较，差异无统计学意义(χ2=0.129，P>0.05)。结论：ALA-PDT治疗寻常性痤疮的疗效略优于红蓝光治疗，但是尚需要大样本量研究证实。

    [关键词]寻常性痤疮；红蓝光治疗；光动力；囊肿

    [中图分类号]R758.73+3 [文献标志码]A [文章编号]1008-6455(2018)12-0063-04

    Comparison of Red and Blue Light Therapy and Aminolevulinic Acid Photodynamic Therapy for Acne

    CHEN Yong-guo，YANG Hui，CUI Jing

    (Department of Dermatology，Aerospace Central Hospital，Beijing 100049，China)

    Abstract： Objective To explore the effects of acne vulgarisvulgaristreatment with red-blue light and aminolevulinic acid photodynamic therapy (ALA-PDT). Methods A retrospective analysis of 64 patients with acne vulgarisvulgariswho were treated in the dermatology department of the Space Center Hospital from January 2015 to October 2017 was performed. According to the treatment of patients， they were divided into control group and observation group. 32 patients in the control group were treated with red and blue light. 32 patients in the observation group were treated with ALA-PDT，compare the effects of treatment. Results The treatment effect of the observation group was better than that of the control group， and the data were statistically significant (z=-2.600， P<0.05). After completion of treatment， the clinical symptom scores of both groups were reduced. The decrease in the observation group was greater than that in the control group， and the data were statistically significant (t=25.108， P<0.05). During the course of treatment， there was no statistically significant difference in the data of various adverse events between the two groups (χ2=0.217， 0.350， 0.736， 0.571， 0.350， P>0.05). There was no significant difference in recurrence data between the two groups (χ2=0.129， P>0.05). Conclusion The therapeutic effect of ALA-PDT is slightly better than that of red and blue light， but it still needs to be confirmed by large sample size study.

    Key words： acne vulgaris； red and blue light therapy photodynamic therapy； cysts

    尋常性痤疮是一种累及毛囊皮脂腺的慢性炎症性皮肤病，受到食物、环境等多种因素影响，发病率近年来逐渐增高[1-2]。目前认为其发病与雄激素、毛囊皮脂腺导管异常角化、痤疮丙酸杆菌等因素有关[3-5]。患者在治疗过程中经常出现病情反复、迁延不愈的情形。如果治疗方法不当或者人为的挤压，可能遗留有瘢痕[6-7]。传统的治疗方法以药物为主，治疗周期长，复发率高，不良反应出现的概率也较高[8]。因此，在临床工作中一直在探索治疗寻常性痤疮的新方法。本文就2015年1月-2017年10月笔者科室采用红蓝光治疗与5-氨基酮戊酸光动力治疗的64例寻常性痤疮患者的病例资料进行回顾性分析，现将结果报道如下。(陈永国 杨慧 崔静)

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