范向宁 刘 柯 朱久育 王 磊 赵清娟 刘 刚 黄艳丽

    [关键词]炎症;肥胖;肝脏;胰岛素;胰岛素抵抗;大鼠

    [中图分类号]R365.4? ? [文献标志码]A? ? [文章编号]1008-6455(2021)12-0102-03

    Effects of Inflammatory Factors on Insulin Signal Pathway in Liver Tissue

    of Obese Rats

    FAN Xiang-ning，LIU Ke，ZHU Jiu-yu，WANG Lei，ZHAO Qing-juan，LIU Gang，HUANG Yan-li

    (Department of Stomatology，the Third Affiliated Hospital of Xinxiang Medical College，Xinxiang 453000，Henan，China)

    Abstract： Objective? The aim of this study was to study the effect of obesity on IR associated with signal pathways in liver. Methods? Ten male SD rats were randomly divided in 2 groups： control group (Con) (fed with standard diet); high-fat diet group (HFD) (fed with high fat diet). The animal model was characterized in terms of body weight (BW) and Lee index. The mRNA levels of tumor necrosis factors ɑ (TNF-ɑ) ......