邹雪莲 胡 雯 康晓静

    [关键词]白癜风;角质形成细胞;细胞因子;氧化应激;细胞免疫

    [中图分类号]R758.4+1? ? [文献标志码]A? ? [文章编号]1008-6455(2021)12-0178-04

    Research Progress of Keratinocytes and the Pathogenesis of Vitiligo

    ZOU Xue-lian1，2，HU Wen1，2，KANG Xiao-jing1，2

    [1.Department of Dermatology，People’s Hospital of Xinjiang Uygur Autonomous Region，Urumqi 830001，Xinjiang，China;2.Xinjiang Key Laboratory of Dermatology Research(XJYS1707)，Urumqi 830001，Xinjiang，China]

    Abstract： Vitiligo is the most common pigmented disorder in dermatology， and its etiology and pathogenesis are still unclear. At present， vitiligo is considered to be an autoimmune disease related to oxidative stress. In recent years， studies have shown that keratinocytes can secrete a variety of cytokines， which affect the normal survival and melanin synthesis of melanocytes through paracrine. When they are in a state of oxidative stress， keratinocytes can act as innate immune cells to initiate the immune response of the body and participate in the pathogenesis of vitiligo. That article will review the role of keratinocytes in the occurrence and development of vitiligo from three aspects： cytokines ......