徐一凤 王淳 张梓菁 吴雪岩 柳大可 曾祥吉 金梅花 韩东河

    [摘要]皮肤衰老是器官老化的最明显表现，其中外部环境和机体内在代谢因素均可加速皮肤老化和退变。研究指出，成纤维细胞的功能改变是导致皮肤衰老的主要原因，与真皮厚度变薄、皮肤干燥、粗糙、光泽降低及弹性减退密切相关。因此，本文将聚焦成纤维细胞自身功能学改变、胶原蛋白合成与代谢、成纤维细胞老化分子机制，探讨成纤维细胞老化与皮肤衰老之间的关系，为研究皮肤衰老提供理论参考。

    [关键词]皮肤衰老；成纖维细胞；胶原合成；真皮；信号通路

    [中图分类号]R339.3+8? ? [文献标志码]A? ? [文章编号]1008-6455(2023)07-0199-03

    The Relationship between the Molecular Mechanism of Fibroblast Aging and Skin Aging and Research Progress

    XU Yifeng1，WANG Chun1，ZHANG Zijing2，WU Xueyan1，LIU Dake1，ZENG Xiangji1，JIN Meihua2，

    HAN Donghe1

    (1.Department of Anatomy，School of Medicine，Dalian University，Dalian 116622，Liaoning，China; 2.Chronic Disease Research Center，Dalian University，Dalian 116622，Liaoning，China)

    Abstract： Skin aging is the most obvious manifestation of organ aging， in which both the external environment and the body's intrinsic metabolic factors， can accelerate skin aging and degeneration. Studies have pointed out that the functional changes of fibroblasts are the main cause of skin aging， which is closely related to thinning of dermal thickness ......