[摘要]现代生活节奏快、压力大等原因，使得越来越多的人受到病理性脱发的困扰。目前脱发的治疗方法仍存在多种挑战，例如药物疗效、副作用、患者依从性、毛囊移植的不利结局等因素。近年来，再生医学和毛发组织工程领域的显著进步，为脱发的干细胞疗法带来了新希望。基于干细胞的治疗方法，可以在实验室环境中产生毛发样结构或操纵其天然生态位中的细胞以重建毛囊。现阶段基于干细胞的脱发治疗可分为三类：干细胞移植、干细胞条件培养基的使用及干细胞外泌体的使用。本文主要总结使用基于干细胞的方法进行脱发治疗的最新进展。

    [关键词]毛囊；干细胞；生态位；毛囊移植；脱发

    [中图分类号]R459.9" " [文献标志码]A" " [文章编号]1008-6455(2023)12-0207-04

    Progress in the Application of Stem Cells in Hair Regeneration

    YANG Qian1，2，LI Min1，2，WANG Gang1，2，DIAO Bo1，2，LIU Yueping1，2

    (1.Department of Medical Laboratory Center，General Hospital of the Central Theater Command，Wuhan 430000，Hubei，China; 2.Hubei Key Laboratory of Central Nervous System Tumor and Intervention，Wuhan 430000，Hubei，China)

    Abstract： Owing to the fast-paced and stressful nature of modern life， an increasing number of people suffer from pathological hair loss. Throughout the current available therapies for hair loss， there are still multiple challenges， such as drug efficacy side effects， patients’ compliance， unfavorable outcomes of follicular transplantation and some unpredictable effects that restrict its application. Recently ......