秦红 邹霓霞 王启华

    [摘要]自然杀伤(Natural kill，NK)细胞是一种固有免疫淋巴样细胞(Innate lymphoid cell，ILP)，是除T细胞、B细胞之外的第三大类淋巴细胞，其特征是无需抗原预先致敏即可快速反应产生非特异性杀伤效果。NK细胞通过分泌穿孔素、颗粒酶、细胞因子和趋化因子等使靶细胞凋亡，还可表达Fc受体(CD16)，介导抗体依赖的细胞介导的细胞毒性作用(Antibody-dependent cell-medicated cytotoxicity，ADCC)。随着年龄增长免疫系统出现功能减退，NK细胞启动适应性免疫应答障碍，不能调动有效免疫反应等生理现象，导致与衰老有关疾病如感染和肿瘤等发生。本文就NK细胞亚群在整个生命周期中的生物学变化来探讨NK细胞与机体衰老的关系，为NK细胞的临床应用打下基础。

    [关键词]NK细胞亚群；衰老；免疫反应；感染；肿瘤

    [中图分类号]R339.3+8? ? [文献标志码]A? ? [文章编号]1008-6455(2024)04-0191-03

    The Biological Changes of Human NK Cell Subsets and Their Relationship with Aging

    QIN Hong， ZOU Nixia， WANG Qihua

    (Hunan Aibikang Technology Co.，LTD， Changsha 410205， Hunan， China)

    Abstract： Natural kill cells (NK cells) is a kind of innate immune lymphoid cells (ILP)， which is the third major type of lymphocyte besides T cells and B cells. It is characterized by rapid reaction without antigen sensitization to produce non-specific killing effect. NK cells induce apoptosis of target cells by secreting perforin， granzyme， cytokines and chemokines， and can also express Fc receptor (CD16) ，which mediates antibody-dependent cell-mediated cytotoxicity (ADCC). With aging ......