[摘要]糖尿病足溃疡(Diabetic foot ulcers，DFUs)是糖尿病晚期的严重并发症，是糖尿病患者致残、致死的主要原因之一，在我国发病率逐年升高，已成为加重社会负担的重大公共卫生问题。DFUs由内外多重因素导致，包括糖代谢紊乱所致皮肤微环境变化、感染、创伤等，往往难以治愈，消耗高昂的医疗资源。因此，找到更有效的疗法非常重要。目前，糖尿病足创面的常规治疗已渐渐被再生医学疗法如干细胞、富血小板血浆、外泌体和功能性RNAs等取代。本文根据最新研究进展对糖尿病足难愈创面的再生医学修复方式予以综述。

    [关键词]糖尿病足溃疡；干细胞；富血小板血浆；外泌体；核糖核酸

    [中图分类号]R259.871 [文献标志码]A [文章编号]1008-6455(2024)10-0178-04

    Research Progress of Regenerative Medicine in Repairing Diabetic Foot Ulcers

    PENG Yan1， DAI Wenting1， NIE Junyi1， XIE Wenqin1， CAO Shuo1， HOU Xiuying2，

    LI Qinyu2， YUAN Peiwen1

    ( 1.The First Clinical Medical College of Shanxi Medical University， Taiyuan 030001， Shanxi， China; 2.Department of Plastic Surgery， the First Hospital of Shanxi Medical University， Taiyuan 030001， Shanxi， China )

    Abstract： Diabetic foot ulcers (DFUs) are serious complications of advanced diabetes and one of the main causes of disability and death in diabetic patients. The incidence of DFUs is increasing year by year in China and has become a major public health problem that increases social burden. DFUs is caused by multiple internal and external factors ......