[摘要]黄褐斑是一种常见的获得性色素沉着性疾病，皮损边缘不规则，呈蝶形对称分布于双颊。高发于育龄期女性，严重影响患者的面貌及心情。目前关于黄褐斑的治疗方法有很多，包括系统的药物治疗、化学换肤及激光治疗，然而这些治疗方法都有自身的局限性。近年来许多研究证实，口服氨甲环酸对黄褐斑具有显著的治疗效果，但口服氨甲环酸有诸多不良反应和禁忌证，致使很多患者不宜使用，而局部使用氨甲环酸可以明显减少不良反应的发生。因此，局部外用、皮内注射、联合微针或激光治疗黄褐斑表现出明显的优势。

    [关键词]氨甲环酸；黄褐斑；皮内注射；微针；激光

    [中图分类号]R758.4+2" " [文献标志码]A" " [文章编号]1008-6455(2024)11-0189-03

    Research Progress of Topical Tranexamic Acid for the Treatment of Melasma

    XU Fan， GONG Chunyan

    ( Department of Pharmacy， Hospital of Dermatology， Chinese Academy of Medical Sciences and Peking Union Medical College， Nanjing 210042， Jiangsu， China )

    Abstract： Melasma is a common acquired pigmentation disorder characterized by irregular borders and symmetrical butterfly-shaped patches on both cheeks. It commonly occurs in women of childbearing age and significantly affects the appearance， emotions and self-confidence of patients. Currently， there are various treatment modalities available for melasma， including systemic pharmacotherapy， chemical peels， and laser treatments. However， these approaches have inherent limitations. In recent years ......