[摘要]聚左旋乳酸(Poly-L-lactic acid， PLLA)是一种不会引起排斥反应、可在生物体内降解的人工合成聚合物，作为一种生物刺激剂，其可沿着与乳酸相同的代谢途径被安全地降解。注射PLLA良好的安全性和较高的患者满意度已被广泛认可，在欧美等国家用于皮肤美容已有超过10年的历史。随着临床经验的累积和研究的开展，注射PLLA的相关手段已较为成熟。本文通过总结PLLA相关研究，对其产品在皮肤美容中的应用进展进行综述。

    [关键词]聚左旋乳酸；皮肤美容；瘢痕治疗；凹陷纠正；年轻化；应用进展

    [中图分类号]R619+.6" " [文献标志码]A" " [文章编号]1008-6455(2024)12-0183-06

    The Progress of Poly-L-lactic acid (PLLA) in Aesthetics

    ZHOU Yuqi， JIAN Zhe

    ( Department of Dermatology， Xijing Hospital， the Fourth Military Medical University， Xi'an 710032， Shaanxi， China )

    Abstract： Poly-L-lactic acid (PLLA) is a synthetic， biocompatible and biodegradable polymer. As a biostimulatory agent， PLLA could be safely degraded the same pathway as lactic acid. The cosmetic application of injectable PLLA has for more than ten years in the western country， and its considerable safety and satisfaction in patients have been identified by many researchers and clinical practitioners. So far， there is a rising number of studies to explore the clinical indication and treatment strategy of PLLA. Through summarizing PLLA-related studies and case reports ......