[摘要]本文通过查阅近年来有关ADSCs及外泌体治疗慢性难愈性创面的文献，分析总结其修复机制及研究最新进展。ADSCs作为组织工程和再生医学理想的种子细胞，具有自我更新和多向分化的潜能，能够显著地调控机体炎症反应与血管生成。ADSCs-Exos具有类似ADSCs的功能，能够加速细胞增殖、分化，促进细胞迁移，调控血管生成速度，是近年来针对慢性创面进行无细胞疗法的研究热点。近年来通过不断开发新的优化方法，使ADSCs及外泌体对创面的修复效果得到进一步增强。但两者在临床应用中仍存在一定局限性，相关研究新进展综述如下。

    [关键词]脂肪来源干细胞；外泌体；慢性创面；创面修复；炎症；血管重建

    [中图分类号]R641" " [文献标志码]A" " [文章编号]1008-6455(2025)03-0171-05

    Research Progress on the Mechanism of Adipose-derived Stem Cells and Exosomes in the Modulation of Chronic Wounds Inflammation and Angiogenesis

    FU Qiang， ZHENG Can， CHEN Minliang

    ( Department of Burn and Plastic Surgery， Plastic and Reconstructive Surgery Unit， Fourth Medical Center， PLA General Hospital， Beijing 100048， China )

    Abstract： The related literatures about chronic wounds treated by ADSCs and ADSCs-Exos in recent years were reviewed， and the repair mechanism was analyzed and summarized. As ideal seed cells for wound healing and tissue regeneration，ADSCs have the potential of self-renewal and multidirectional differentiation. It can significantly regulate inflammatory response and angiogenesis. ADSCs-Exos have similar functions to ADSCs ......