[摘要]羟基磷灰石人工骨是最有前途的生物医用材料之一，在骨科领域和药物释放方面有着广泛的应用和研究。然而单独的羟基磷灰石脆性高，降解速度慢，限制了其在临床上的使用。聚合物在结构上与细胞外基质类似，具有良好的生物相容性，可调控的生物降解性。羟基磷灰石/壳聚糖复合材料具有良好的生物相容性和合适的力学性能，逐渐成为骨修复生物材料研究的热点。本文综述了羟基磷灰石/壳聚糖复合材料的制备及其在骨组织再生中的应用，并对羟基磷灰石/壳聚糖复合材料的研究发展方向进行展望。

    [关键词]羟基磷灰石；壳聚糖；复合材料；生物材料；药物递送

    [中图分类号]R681" " [文献标志码]A" " [文章编号]1008-6455(2025)03-0189-04

    Preparation of Hydroxyapatite/Chitosan Composite and Its Application in Bone Tissue Regeneration

    PENG Ximing1， ZHOU Chuchao2， YANG Yanqing2

    ( 1.Department of Medicine， Medical College of Wuhan University of Science and Technology， Wuhan 430065， Hubei， China; 2.Department of Plastic Surgery， Wuhan Third Hospital， Tongren Hospital of Wuhan University， Wuhan 430060， Hubei， China )

    Abstrat： Hydroxyapatite (HA) artificial bone is one of the most promising biomedical materials and has been widely used and studied in the field of orthopedics and drug delivery. However， hydroxyapatite alone has high fragility and slow degradation， which limits its clinical use. The polymer is structurally similar to the extracellular matrix， has good biocompatibility ......