[摘要]目的：观察填充聚左旋乳酸以改善鼻唇沟过深的临床效果。方法：选择2021年12月-2022年5月笔者医院收治的52例鼻唇沟填充就医者，注射聚左旋乳酸，在初始治疗后的即刻、完成3次治疗后的第3个月、第6个月及第12个月评价注射后的效果及不良反应。结果：本组52例就医者，注射后3 d内均存在皮肤轻度红肿及轻微触压痛的反应，多数就医者在3 d内消退，仅两例就医者延迟至5 d消退。在随访期内所有就医者均未出现感染、结节、囊肿或肉芽肿等并发症。16例就医者在初始治疗结束后的1个月内即出现明显的软组织填充且无其他不适感。28例就医者在初始治疗完成后的第12个月WSRS评分显示不仅未回退至基线水平且维持了良好的填充效果。本次治疗有效率为88.46%(46/52)，满意率为84.61%(44/52)。结论：采用聚左旋乳酸填充对鼻唇沟过深的改善效果明显，且安全可靠，操作简单，并发症少。

    [关键词]鼻唇沟；聚左旋乳酸；生物刺激剂；面部老化；填充剂

    [中图分类号]R622" " [文献标志码]A" " [文章编号]1008-6455(2025)04-0020-03

    Clinical Efficacy Observation of Poly-L-lactic Acid in Nasolabial Fold Filling

    DING Qingfeng1， SONG Zijun2， WO Beibei2

    ( 1.Shijiazhuang YAFANGYA Aesthetic Hospital， Shijiazhuang 050030， Hebei， China; 2.Shijiazhuang Joyful Aesthetic Clinic， Shijiazhuang 050081， Hebei， China )

    Abstract： Objective" To observe the therapeutic effect of injectable poly-L-lactic acid in nasolabial fold augmentation. Methods" 52 patients with nasolabial fold augmentation who were treated at the author's hospital from December 2021 to May 2022 were selected to receive poly-L-lactic acid injection. The efficacy and adverse reactions of the injection were evaluated immediately after initial treatment and at the 3rd ......