[摘要]目的：探讨曲安奈德注射联合点阵CO2激光治疗增生性瘢痕睑黄瘤的美学效果。方法：选取2021年2月-2023年2月笔者医院收治的146例增生性瘢痕睑黄瘤患者，依照随机数字表法随机分为对照组和观察组各73例，对照组单纯给予患处局部注射曲安奈德治疗，观察组给予曲安奈德注射联合点阵CO2激光治疗，在治疗6个月后评定两组的临床疗效，比较两组治疗前及治疗6个月后的瘢痕情况[温哥华瘢痕量表(Vancouver scar scale，VSS)]、血清生化指标[血管内皮生长因子(Vascular endothelial growth factor，VEGF)、转化生长因子-β1(Transforming growth factor-β1，TGF-β1)]，记录两组不良反应发生情况。结果：观察组的总有效率显著高于对照组(91.78% vs. 79.45%，P<0.05)；治疗后，两组VSS量表中关于色泽、血管分布、柔软度及厚度共4项评分较治疗前有显著性降低(P<0.05)，其中观察组显著低于对照组(P<0.05)；治疗后，两组血清VEGF、TGF-β1水平较治疗前有显著性降低(P<0.05)，其中观察组显著低于对照组(P<0.05)；两组的不良反应总发生率差异无统计学意义(P>0.05)。结论：曲安奈德注射联合点阵CO2激光治疗增生性瘢痕睑黄瘤的美学效果明确，能提高总有效率，改善瘢痕增生情况，并可降低血清VEGF、TGF-β1水平，减少不良反应，临床应用安全、有效。

    [关键词]曲安奈德注射；点阵CO2激光；增生性瘢痕睑黄瘤；美学效果；血管内皮生长因子；转化生长因子-β1

    [中图分类号]R779.6" " [文献标志码]A" " [文章编号]1008-6455(2025)07-0086-04

    Cosmetic Effect of Triamcinolone Acetonide Injection Combined with Fractional" CO2" Laser in the Treatment of Hypertrophic Scar with Xanthelasmata

    DING Li， GU Junying， JI Xiaofan

    [ Shanghai Baoshan District Wusong Central Hospital ( Zhongshan Hospital Wusong Branch， Fudan University )， Shanghai 200940， China ]

    Abstract： Objective" To explore the cosmetic effect of triamcinolone acetonide injection combined with fractional CO2 laser in the treatment of hypertrophic scar with xanthelasmata. Methods" 146 patients with hyperplastic scar and xanthelasmata admitted to the hospital from February 2021 to February 2023 were selected and randomly divided into control group and observation group with 73 cases in each group according to the random number table method. The control group was treated with local injection of triamcinolone acetonide ......