[摘要]目的：探索氦氖激光联合复方黄柏液治疗皮肤慢性创面的临床效果。方法：选取2021年5月-2023年5月于笔者医院皮肤科治疗的153例皮肤慢性创面患者，随机分为对照组(n=77)和观察组(n=76)，对照组给予复方黄柏液治疗，观察组给予氦氖激光联合复方黄柏液治疗，疗程共4周，比较两组患者疼痛缓解时间、创面愈合时间、首次治疗前、治疗14 d、21 d创面分泌物生物学指标以及不良反应发生情况。结果：疼痛缓解时间方面，观察组为(2.34±0.56)d，对照组为(3.10±0.80)d，观察组短于对照组(P<0.05)；创面愈合时间方面，观察组为(20.99±2.39)d，对照组为(22.22±2.66)d，观察组短于对照组(P<0.05)；首次治疗前，两组创面分泌物肿瘤坏死因子α(TNF-α)、白细胞介素1β(IL-1β)、碱性成纤维细胞生长因子(bFGF)、表皮细胞生长因子(EGF)水平比较，差异无统计学意义(P>0.05)；治疗14 d及21 d后，两组TNF-α、IL-1β水平均降低，且观察组更低(P<0.05)；治疗14 d及21 d后，两组bFGF、EGF水平均升高，且观察组更高(P<0.05)。两组治疗期间不良反应发生率比较差异无统计学意义(P>0.05)。结论：氦氖激光联合复方黄柏液可有效促进皮肤慢性创面愈合，且具有较好的安全性，值得临床上推广应用。

    [关键词]氦氖激光；复方黄柏液；皮肤慢性创面；随机对照分析；炎症因子；疗效

    [中图分类号]R751.05" " [文献标志码]A" " [文章编号]1008-6455(2025)08-0125-04

    Effect of He-Ne Laser Combined with Compound Phellodendron Liquid on Chronic Skin Wound

    WANG Jing， HAN Shu， ZHU Xin

    ( Department of Dermatology， the First Affiliated Hospital of Xi'an Medical University， Xi'an 710077， Shaanxi， China )

    Abstract： Objective" To explore the clinical effect of He-Ne laser combined with compound phellodendron liquid in the treatment of chronic skin wound. Methods" A total of 153 patients with chronic skin wound who were treated in the Dermatology of the Hospital from May 2021 to May 2023 were randomly divided into control group (n=77) and observation group (n=76). The control group was treated with compound phellodendron liquid. The observation group was treated with He-Ne laser combined with compound phellodendron liquid for 4 weeks. The pain relief time ......