[摘要]目的：探究RubyStar 694 nm调Q红宝石点阵激光与果酸换肤联合治疗黄褐斑的临床效果。方法：纳入2021年4月-2024年4月于笔者医院接受治疗的黄褐斑患者140例进行回顾性分析，依据治疗方案不同分为激光组(n=67，RubyStar 694 nm调Q红宝石点阵激光)和联合组(n=73，RubyStar 694 nm调Q红宝石点阵激光+果酸换肤)。比较两组的临床疗效，比较两组治疗前后的黄褐斑面积和严重指数(MASI)、皮损颜色、皮损面积评分和炎症指标，评价两组的安全性和美观满意度。结果：联合组的治疗总有效率高于激光组(P<0.05)；末次治疗后3个月，联合组的MASI、皮损颜色、皮损面积评分明显低于激光组(P<0.05)；末次治疗后3个月，联合组的血清白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、白介素-1β(IL-1β)水平低于激光组(P<0.05)；两组不良反应比较差异无统计学意义(P>0.05)；治疗后3个月联合组的美观满意度高于激光组(P<0.05)。结论：RubyStar 694 nm调Q红宝石点阵激光与果酸换肤联合治疗黄褐斑的效果明显，可有效改善患者的炎症反应及面部症状，且无明显不良反应，患者的美观满意度较高。

    [关键词]黄褐斑；调Q红宝石点阵激光；果酸；炎症反应；面部症状；美观满意度；联合治疗

    [中图分类号]R758.42" " [文献标志码]A" " [文章编号]1008-6455(2025)09-0104-04

    Clinical Study on the Treatment of Chloasma with RubyStar Q-switched Laser Combined with Glycolic Acid Peelization

    SHI Xiubo， SHE Donghua， LAN Xiaoqiong， HE Guorong

    ( Department of Dermatology and Venereology， Hospital of Chengdu Office of People’s Government of Xizang Autonomous Region， Chengdu 610041， Sichuan， China )

    Abstract： Objective" To explore the clinical effect of combination of RubyStar 694 nm Q-switched laser and glycolic acid peeling in the treatment of chloasma. Methods" Totally 140 patients with chloasma who received treatment in the hospital were included from April 2021 to April 2024 for retrospective analysis. According to different treatment regimens ......